Dr. Eddy applies probabilistic modeling methods and other computational algorithms to the study of the evolution of genomes. As a "computational geneticist", he develops and uses computer algorithms to screen for interesting genetic features in large-scale DNA sequences. His team collaborates closely with genome sequencing groups at the Genome Sequencing Center at Washington University and the Sanger Centre in Cambridge England. Dr. Eddy’s long-term intellectual interest is in RNA computational molecular archaeology, identifying novel structural and catalytic RNAs. He says, “We hope that we might be able to learn something about the origins of life by identifying new RNA genes and studying their evolutionary history.”